Glial fibrillary acidic protein, or GFAP, is a type III intermediate filament protein, composing of three domains: head, rod and tail. DNA sequence of the rod domain is highly conserved. It belongs to the intermediate filament protein family. GFAPs are expressed in many human cells including ependymal cells and astrocytes during development. Other human cells such as keratinocytes, Leydig cells, chondrocytes, and osteocytes also express GFAPs.
GFAP is an intermediate filament protein. It is non-epithelial cell type, which contributes to the organization of the cytoskeleton. In humans, the GFAP biomarker gene encodes the GFAP protein. This protein’s three domains include rod, head, and tail. The rod domain is the only region that remains highly conserved in different species. GFAP is a glial fibrillary acidic protein that is present in astrocytes, ependymal cells, and some neurons. Not only does GFAP maintain cell shape and help astrocyte mechanical strength, but it also has an important role for OPCs (oligodendrocyte precursor cells). It is an intermediate filament protein of the cytoskeleton family and arises from GFAP gene located on chromosome 17 in humans.
GFAP is a type of protein in the body. It is produced by glial cells, a type of neural cell. This specific protein helps cells talk to each other. Specifically, GFAP has four parts: the head is the protein domain that glial cells use to signal to other cells; the rod helps to hold the GFAP together; the tail sets up where GFAP will go in a cell; and, finally, signaling molecules attach to GFAPs so they know how to direct cell communication.
The GFAp biomarker is a type III intermediate filament protein belonging to the intermediate filament protein family. The GFAP gene in humans encodes the GFAP protein. The gene is located on chromosome 17. Several CNS cell types that include ependymal cells and astrocytes express GFAP proteins during development. Other human cells, such as keratinocytes, Leydig cells, chondrocytes, and osteocytes, also express GFAP.
Cystatin C assay is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. CST3 gene encodes cystatin C, which belongs to the gene family of type 2 cystatin.
Cystatin C is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. Renal disease markers such as cystatin C are extremely useful in the diagnosis of kidney diseases. A blood sample usually provides a cystatin C result which is converted to an estimated glomerular filtration rate (eGFR). Alongside creatinine levels, this gives a clearer picture of renal function. Cystatin C levels can also reveal other pathologies.
Cystatin C test is a blood test that measures the cystatin C protein level in blood. The kidney filters, or cleans, the blood using nephrons. Cystatin C is a protein that the cells in the body make and shed into the blood all of the time. Cystatin C has anti-inflammatory properties that prevent damage to healthy cells and tissue.
